Microwave-Assisted Method for Synthesis of 1,3-Disubstituted Pyrroles

Abstract

1,3-Disubstituted pyrroles were prepared by a microwave-assisted reaction of pyrrolidine and aldehydes in toluene as well as in solvent-free conditions. Reactions were completed in a few minutes in the solvent-free condition but a long time (up to 30 min) was necessary to complete reactions in toluene. Yields of products depended considerably on the aldehyde used.

Keywords:

• Microwave assisted
• pyrroles
• solvent free

ACKNOWLEDGMENTS

We thank Dr. B. Horvath and his staff for ¹H and ¹³C NMR analyses and Dr. R. Kubinec and his staff for GC-MS analyses, both from the Institute of Chemistry of Faculty of Natural Sciences, Comenius University. The financial support of the Ministry of Education of the Slovak Republic is acknowledged. This work was carried out as a part of the COST D32/0010/2002 project.

Notes

^a Yield of reaction performed under thermal heating (reaction time 12–20 h) as reported in Ref. 6.