New Efficient Protocol for the Production of Hantzsch 1,4-Dihydropyridines Using RuCl₃

Abstract

Hantzsch 1,4-dihydropyridines are synthesized in a few minutes and in good to excellent yields from aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate. The reaction is performed in solvent-free conditions, and 5 mol% of RuCl₃ is enough for this protocol.

Keywords:

• Aldehydes
• ammonium acetate
• 1,3-dicarbonyl compound
• Hantzsch 1,4-dihydropyridines
• RuCl₃
• solvent free

ACKNOWLEDGMENTS

The authors are thankful to the Council of Scientific and Industrial Research, New Delhi, India, for financial assistance and to the Indian National Science Academy, New Delhi, India, for additional financial support for this research project.

Notes

^a The products were characterized by comparison of their melting points and spectral (IR, ¹H NMR) data with those of authentic samples.

^b Isolated yields after recrystallization.