Facile Synthesis of Second-Generation Dendrons with an Orthogonal Functional Group at the Focal Point

Abstract

Facile synthesis of second-generation dendrons with an aldehyde, epoxy, or t-Boc group at the focal point and nine carboxylic acid groups at the periphery is reported. The scheme includes a coupling of the first-generation dendrons and a two-step, one-pot reaction that proceeds through a Boc deprotection and in situ conjugation at the focal point.

Keywords:

• Dendrons
• deprotection
• divergent
• epoxy

ACKNOWLEDGMENTS

We are grateful for financial support from the Korea Research Foundation (KRF-2004-005-C00007). We thank Prof. Young Ho Rhee for his valuable suggestions.