Abstract
Cu(OAc)2-catalyzed C-N bond-formation reaction of sulfonamides with organoboronic acids or trimethoxy(phenyl)silane was achieved in the presence of 20 mol% of Cu(OAc)2, providing N-arylation products with yields ranging from moderate to good.
ACKNOWLEDGMENTS
We thank the National Natural Science Foundation of China (No. 20504023) and the Science and Technology Projects of Zhejiang Province (No. 2006C31030) for financial support.
Notes
a Reaction conditions: 4-methylbenzenesulfonamide (0.2 mmol), phenylboronic acid (0.3 mmol), base (0.3 mmol), solvent (2 mL), 90 °C, 12 h.
a All reactions were run with sulfonamides (0.2 mmol), arylboronic acids (0.3 mmol), Cu(OAc)2 (7.4 mg, 20 mol%), and K2CO3 (0.3 mmol) in 2 mL dry isopropanol at 90 °C in a sealed tube for 12 h.