Abstract
Cs2CO3-catalyzed transamination of primary amines and ethylene carbonate proceeds to form 1,3-disubstituted symmetrical/unsymmetrical ureas in excellent yields. The effect of different reaction parameters such as influences of bases, temperature, and reaction time were investigated for the title reaction.
ACKNOWLEDGMENT
The financial support from the Technical Education Quality Improvement Program (TEQIP), Government of India, is acknowledged.
Notes
a Yields refer to isolated pure products characterized by IR, GC-MS, and 1H NMR.
Notes. Reaction conditions: butyl amine: 20 mmol, ethylene carbonate: 10 mmol; temp.: 90 °C, base: 0.2 mmol, and time: 20 min.
a Yields refer to isolated pure products characterized by IR, GC-MS, and 1H NMR.
Notes. Reaction conditions: amine: 20 mmol, ethylene carbonate: 10 mmol, Cs2CO3: 0.2 mmol.
a Yields are based on GC analysis.
Notes. Reaction conditions: ethylene carbonate (10 mmol) was reacted with amine (1; 10 mmol) at 70 °C for 1 h, and then the formed 2-hydroxycarbamate was reacted with amine (4; 10 mmol) at 100 °C for 30 min using 0.2 mmol Cs2CO3.