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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 13
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Original Articles

Iodine-Catalyzed Mild and Efficient Method for the Synthesis of Chalcones

, &
Pages 2288-2296 | Received 13 Aug 2008, Published online: 01 Jun 2009
 

Abstract

Molecular iodine is found to catalyze the condensation of acetophenones with various aromatic aldehydes to prepare chalcones.

ACKNOWLEDGMENTS

The Authors are grateful to the director, CDRI, Lucknow, India, for constant encouragement for the drug development program, SAIF for 300-MHz NMR and mass spectral data, and S. P. Singh for technical support. J. N. R. and A. K. thank the University Grants Commission and the Council of Scientific and Industrial Research, New Delhi, India, respectively for financial support.

Notes

a All the products were characterized 1H NMR, 13C NMR, and mass spectroscopy.

b Isolated yields after column chromatography.

Part 4 in the series Studies on Novel Synthetic Methodologies. CDRI Communication No. 7418.

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