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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 13
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Original Articles

Copper Acetate–Catalyzed, Mild, Highly Efficient, and Practical Synthesis of Thiazoles and Aminothiazoles

, &
Pages 2317-2320 | Received 08 Sep 2008, Published online: 01 Jun 2009
 

Abstract

A mild and highly efficient synthesis of thiazoles by the condensation of α-bromo ketones with thiourea in the presence of a catalytic amount of copper acetate at room temperature has been described. The method is applicable for a variety of aryl and alkyl α-bromo ketones. The catalyst is inexpensive, and substituted thiazoles are obtained in good yields.

ACKNOWLEDGMENTS

D. A. and B. R. V. P. thank the Counsil of Scientific and Industrial Research for the award of a fellowship and J. S. Yadav, director, Indian Institute of Chemical Technology, for his support and encouragement.

Notes

a All the products were characterized by 1H NMR, IR, and mass spectroscopy.

b Isolated yields after purification.

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