Abstract
A series of three-component reactions has been carried out using HClO4-SiO2 as a versatile heterogeneous catalyst. A series of new and novel N-protected 1-aminoalkyl-2-naphthol derivatives have been prepared under thermal solvent-free reaction conditions. In all cases, the reaction conditions were very simple and high-yielding.
ACKNOWLEDGMENT
We are thankful to the Sistan and Baluchestan University Research Council for the partial support of this research.
Notes
a 0.07 g of HClO4-SiO2 equal to 0.035 mmol of H+, and the molar ratio of the catalyst to substrate is 3.5 mol%.
b Yields refer to the isolated pure product, and the molar ratio of benzaldehyde/ 2-naphthol/methyl carbamate is 1/1/1.2.
a Yields refer to the isolated pure products; the reaction was carried out under thermal solvent-free conditions in an oil bath at 85°C. The molar ratio of aldehydes/2-naphthol/methyl or benzyl carbamate/catalyst was 1/1/1.2/0.035.
b Isolated yields after five catalyst recoveries.