Abstract
A series of 3-acetoacetylcoumarin derivatives were synthesized via the reaction of substituted 2-hydroxybenzaldehydes and 4-hydroxy-6-methyl-2H-pyran-2-one in ionic liquid. This method has the advantages of good yields, milder reaction conditions, easier workup, no catalyst, and environmentally benign procedure.
ACKNOWLEDGMENTS
We are grateful to the Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province and the Key Laboratory of Biotechnology on Medical Plants of Jiangsu Province for financial support.