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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 39, 2009 - Issue 9
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Original Articles

Synthesis of 2-(Thiophen-3-yl)vinylphosphonic Acid

, , &
Pages 1511-1515 | Received 04 May 2007, Published online: 02 Apr 2009
 

Abstract

A simple and efficient synthesis of 2-(thiophen-3-yl)vinylphosphonic acid has been developed. The title compound is obtained in 70% yield by addition of thiophene-3-carbaldehyde to lithium diethyl methylenephosphonate, followed by dehydration and hydrolysis. 1H, 13C, and 31P NMR spectra are presented for each of the intermediates.

ACKNOWLEDGMENTS

We are grateful to Consejo Nacional de Ciencia y Tecnología (CONACYT) for financial support through grants 48356-Q and C02-44704. We are indebted to Graciela I. González-Castillo for technical support and Dr. Herbert Höpfl for many important observations.

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