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Abstract
A facile one-pot synthesis of nitriles starting with aldehydes has been developed employing hydroxylamine hydrochloride in dimethylsulfoxide at 100°C.
ACKNOWLEDGMENT
The authors gratefully acknowledge financial support from the Research Corporation, the University of Chattanooga Foundation, and the Grote Chemistry Fund.
Notes
a Isolated yields.
b Nitrile purities >95% as determined by 1H-NMR.
c Monitored by GC-MS.