Abstract
The direct reaction of o-aminopyrazocarbonitriles and carbonyl compounds to afford pyrazolopyrimidinones was discovered; hence, a simultaneous synthetic method for pyrazolopyridines and pyrazolopyrimidinones was achieved. Under microwave irradiation, better yields of products than those of conventional method were given.
Notes
a All reactions were carried out at variable power in a Biotage microwave reactor for 10 min using 1 (4 mmol), ZnCl2 (4.2 mmol), and 2 (3 mL).
b Isolated yield.