Abstract
The second- and third-generation multiple dendrimers based on naproxen in core and Asp(4–6) oligopeptides in periphery were synthesized in a convergent approach and well characterized by NMR and mass spectral (MS) techniques. These conjugates showed a high affinity to hydroxyapatite in vitro and provided an effective entry for the synthesis of a peptide dendrimer used for bone targeting.
Notes
a Naproxen dissolved in anhydrous CH3OH.