Convenient Synthesis of N-Hydroxysuccinimide Esters from Carboxylic Acids Using Triphosgene

Abstract

A simple and convenient method for the synthesis of N-hydroxysuccinimide ester is developed using triphosgene as an acid activator. Several aromatic and aliphatic N-hydroxysuccinimide esters are prepared from their corresponding carboxylic acids at room temperature in good yields in a rapid process using triphosgene. Some of the major advantages are mild conditions, good yields, and easy operation.

Keywords:

• Carboxylic acids
• N-hydroxysuccinimide
• N-hydroxysuccinimide esters
• triphosgene

ACKNOWLEDGMENT

We gratefully acknowledge financial support from Hankyong National University.

Notes

^a Yields refer to isolated products.