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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2009 - Issue 1
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Original Articles

Synthesis and Evaluation of Novel Compounds as Potent Dipeptidyl Peptidase IV Inhibitors

Liutang Wang West China School of Pharmacy, Sichuan University, Chengdu, China; Department of Research and Development, Di'ao Co. Ltd, Chengdu, China
,
Bin Zhang Department of Research and Development, Di'ao Co. Ltd, Chengdu, China
,
Jianxin Ji Department of Research and Development, Di'ao Co. Ltd, Chengdu, China
,
Bogang Li Department of Research and Development, Di'ao Co. Ltd, Chengdu, China
,
Jufang Yan Department of Research and Development, Di'ao Co. Ltd, Chengdu, China
,
Weiyu Zhang Department of Research and Development, Di'ao Co. Ltd, Chengdu, China
,
Yong Wu West China School of Pharmacy, Sichuan University, Chengdu, ChinaCorrespondence[email protected]
,
Xuechao Wang West China School of Pharmacy, Sichuan University, Chengdu, China; Department of Research and Development, Di'ao Co. Ltd, Chengdu, ChinaCorrespondence[email protected]
&
Hui Hou Department of Research and Development, Di'ao Co. Ltd, Chengdu, China
 show all
Pages 52-57 | Received 17 Dec 2008, Published online: 09 Dec 2009
 
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Abstract

A series of new 2-cyanopyrrolidine derivatives with constrained imidazolidin ring were synthesized, Their structures were confirmed by 1H NMR spectroscopy and/or mass spectrometry, and their activities were evaluated in vitro. They were proven to possess submicromolar inhibitory activities against dipeptidyl peptidase IV.

Notes

Note. Values are IC50 (μM) expressed as the mean of three independent determinations.

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