Trimethylsilyl Chloride as a Promoter for the Groebke–Blackburn Reaction: Preparation of Imidazo[2,1-b][1,3]Benzothiazoles

Abstract

2-Amino[1,3]benzothiazoles can be efficiently used as substrates for the Groebke–Blackburn (GB) reaction using equimolar trimethylsilyl chloride (TMSCl) as a promoter. This finding extends the utility of TMSCl in isocyanide-based multicomponent reactions (MCRs) and expands the scope of reactive 2-aminoazole participants for the GBMCR.

Keywords:

• Groebke–Blackburn reaction
• imidazo[1,2-x]azoles
• isocyanide-based multicomponent reactions
• trimethylsilyl chloride

Notes

^a The number in parentheses indicates the yield after crystallization.