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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2009 - Issue 2
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Original Articles

Efficient Synthesis of 6-Amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitrile Under Solvent-Free Conditions

Liangce Rong College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China; Key Laboratory of Biotechnology for Medicinal Plants, Xuzhou, Jiangsu, ChinaCorrespondence[email protected]
,
Lijiu Gao College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China
,
Hongxia Han College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China
,
Hong Jiang Key Laboratory of Biotechnology for Medicinal Plants, Xuzhou, Jiangsu, China
,
Yisi Dai College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China
&
Shujiang Tu College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China; Key Laboratory of Biotechnology for Medicinal Plants, Xuzhou, Jiangsu, China
Pages 289-294 | Received 01 Dec 2008, Published online: 29 Dec 2009
 
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Abstract

A series of 6-amino-8-aryl-2-methyl-1,2,3,4-tetrahydroisoquinoline-5,7-dicarbonitriles were prepared in good yields under solvent-free conditions by multicomponent reactions of aromatic aldehyde, malononitrile, and 1-methylpiperidin-4-one in the presence of sodium hydroxide (NaOH). The structures of the products were characterized by infrared, 1H NMR spectra, elemental analysis, and high-resolution mass spectrometery (HRMS).

ACKNOWLEDGMENTS

We thank the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Pei Yu Foundation (No. 07PYL06) of Xuzhou Normal University for financial support.

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