Facile and Simple Synthesis of Novel 1-Methyl-2-(2-substituted-oxazol-4-yl)-1H-benzimidazole Derivatives

Abstract

Novel 1-methyl-2-(2-substituted-oxazol-4-yl)-1H-benzimidazole derivatives were obtained in good yields and purity by treating corresponding 2-benzimidazolyl esters with acetamide in the presence of BF₃-etherate, a Lewis acid.

Keywords:

• Acetamide
• 2-benzimidazolyl ester
• Lewis acid
• oxazole

ACKNOWLEDGMENTS

The authors thank Dr. Reddy's Laboratories Ltd. for supporting this work. The authors also thank Mr. Abhijit Mukherjee and Dr. Vilas Dahanukar for their constant help and encouragement. The cooperation extended by all colleagues of the analytical division is gratefully acknowledged.