Chemoselective Synthesis of 1,1-Diacetates from Aldehydes Using Anhydrous Cobalt(II) Bromide Under Solvent-Free Conditions

Abstract

A mild and efficient method has been developed for the chemoselective preparation of 1,1-diacetates (acylals) from aldehydes catalyzed in the presence of a catalytic amount (0.1 mmol) of anhydrous cobalt(II) bromide under solvent-free conditions. The remarkable selectivity under mild and neutral conditions, excellent yields, short reaction time, and easily available and inexpensive catalyst are important features of this method.

Keywords:

• Chemoselective
• cobalt dibromide
• 1,1-diacetates
• solvent-free

ACKNOWLEDGMENT

We thank the Faculty of Chemistry, University of Mumbai, India, for supporting this work.

Notes

^a Isolated yield.

^b The solvent-free reaction is more effective.

^a Isolated yield of the corresponding sulfonylated product.

^a Yields refer to pure products, and all products were characterized by comparison of their infrared (IR) and ¹H NMR spectra.