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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 4
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Original Articles

Efficient and Facile Synthesis of 2,4-Diamino-6-arylpyrimidine-5-carbonitrile Under Solvent-Free Conditions

Liangce Rong College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China; Key Laboratory of Biotechnology for Medicinal Plants, Jiangsu Province of Xuzhou, Jiangsu, ChinaCorrespondence[email protected]
,
Hongxia Han College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China
,
Lijiu Gao College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China
,
Yisi Dai College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China
,
Minxia Cao College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China
&
Shujiang Tu College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, China; Key Laboratory of Biotechnology for Medicinal Plants, Jiangsu Province of Xuzhou, Jiangsu, China
Pages 504-509 | Received 21 Jan 2009, Published online: 03 Feb 2010
 
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Abstract

An efficient and convenient method for the preparation of 2,4-diamino-6-arylpyrimidine-5-carbonitrile derivatives by the one-pot reaction of aromatic aldehydes, malononitrile, and guanidine carbonate, in the presence of sodium hydroxide under solvent-free conditions, was reported. This method has the advantages of excellent yields, mild reaction conditions, easy work up, and environmental friendliness over the existing procedures.

ACKNOWLEDGMENTS

We thank the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Pei Yu Foundation (No. 07PYL06) of Xuzhou Normal University for financial support.

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