Abstract
4-Chloro-5-fluoro-2-aryl-3(2H)-pyridazinones were obtained by the fluorination of 4,5-dichloro-2-aryl-3(2H)-pyridazinones with ethylhexamethylenetetramine fluoride in excellent yields. The ethylhexamethylenetetramine fluoride was synthesized by the reaction of hydrofluoric acid with ethylhexamethylenetetramine hydroxide prepared from ethylhexamethylenetetramine bromide and alkali.
Notes
a Reaction conditions: 5a (1 mmol), fluorination reagent (2 mmol), solvent (10 mL), 8h.
b Isolated yield.
a All products were characterized by 1H NMR, MS, and IR.
b Isolated yields.