Oxidative Aromatization of Hantzsch 1,4-Dihydropyridines by H₂O₂/V₂O₅ at Room Temperature

Abstract

A mild and highly efficient synthetic method was developed for the aromatization of 1,4-dihydropyridines employing H₂O₂ and 5 mol% of V₂O₅. The reactions were carried out in CH₃CN to give pyridine compounds in excellent yields.

Keywords:

• Aromatization
• H₂O₂
• Hantzsch 1,4-dihydropyridines
• V₂O₅

ACKNOWLEDGMENT

The authors are grateful to Southwest University of China for financial support.

Notes

^a All reactions were carried out at room temperature in CH₃CN.

^b Isolated yields.