Melamine Trisulfonic Acid (MTSA): A New Efficient Catalyst for the Chemoselective Methoxymethylation of Alcohols

Abstract

Melamine trisulfonic acid, which is easily prepared by the reaction of melamine with neat chlorosulfonic acid, is able to efficiently catalyze the chemoselective methoxymethylation of alcohols with dimethoxymethane (DMM). All reactions were performed under mild and completely heterogeneous reaction conditions in good to high yields.

Keywords:

• Alcohols
• heterogeneous reaction conditions
• melamine
• melamine trisulfonic acid
• methoxymethylation

ACKNOWLEDGMENT

We are thankful to the University of Guilan Research Council for the partial support of this work.

Notes

^a Products were characterized by comparison of their physical and spectral data with authentic samples.^{[ 4 , 11 , 13,14]}

^b Isolated yields.

^c Conversion.