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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 7
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Original Articles

Mild and Efficient Procedure for Michael Addition of N-Heterocycles to α,β-Unsaturated Compounds Using Anhydrous K3PO4 as Catalyst

, , , &
Pages 973-979 | Received 07 Feb 2009, Published online: 04 Mar 2010
 

Abstract

Imidazole, 1,2,4-triazole, indole, and benzotriazole undergo conjugate additions with α, β-unsaturated carbonyl compounds in the presence of anhydrous potassium phosphate at ambient temperature to afford the corresponding Michael adducts in excellent yields.

ACKNOWLEDGMENTS

We thank the West Light Foundation of the Chinese Academy of Sciences (CAS, O729361401) for the financial support. Research was also supported by the CAS/State Administration of Foreign Experts Affairs (SAFEA) International Partnership Program for Creative Research Teams.

Notes

a Isolated yield by silica-gel column chromatography.

a Isolated yield by silica-gel column chromatography.

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