H₆P₂W₁₈O₆₂-18H₂O, a Green and Reusable Catalyst for the Three-Component, One-Pot Synthesis of 4,6-Diarylpyrimidin-2(1H)-ones Under Solvent-Free Conditions

Abstract

Three-component, one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones and 9-phenyl-8-oxa-10,12-diaza-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5-trien-11-one by condensing acetophenone derivatives, aldehydes, and urea in the presence of trimethylsilyl chloride using a catalytic amount of H₆P₂W₁₈O₆₂-18H₂O under solvent-free conditions is reported.

Keywords:

• 4,6-Diarylpyrimidin-2(1H)-ones
• heteropolyacids
• H₆P₂W₁₈O₆₂-18H₂O
• 9-phenyl-8-oxa-10,12-diaza-tricyclo[7.3.1.0^2,7]trideca-2(7),3,5-trien-11-one
• solvent-free reactions

ACKNOWLEDGMENT

The authors are thankful to Azzahra Research Council for the partial financial support.

Notes

^a Yields are related to isolated pure products.

^b Catalyst was reused for three times.

^c The reaction was carried out without catalyst.

^d The reaction was carried out without TMSCl.

^e TMSCl was replaced by p-toluene sulfonyl chloride, and the reaction was carried out in acetonitrile as solvent in 70 °C.

^a Yields are related to isolated pure products.

^b Compount 2b obtained as product.

^c Compound 3a obtained as product.