Simple and Efficient Synthesis of 2-Aryl-2,3-Dihydroquinolin-4(1H)-ones Using Silica Chloride as a New Catalyst Under Solvent-Free Conditions

Abstract

A mild, efficient, and high-yielding method for the synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-ones from their corresponding 2-amino chalcones using silica chloride (SiO₂Cl) under solvent-free conditions is described. A series of 2-aryl-2,3-dihydroquinolin-4(1H)-ones containing both electron-donating and electron-withdrawing substituents were synthesized.

Keywords:

• 2-Amino chalcones
• 2-aryl-2,3-dihydroquinolin-4(1H)-ones
• microwave
• silica chloride

ACKNOWLEDGMENTS

Financial assistance from the Department of Science and Technology, New Delhi (Project SR/FTP/CS-25/2007) is gratefully acknowledged. The authors thank Dr. Pradeep Kumar, FNASc, for his constant encouragement and support.

Notes

^a Microwave irradiation was carried out at 600 W.

^b Isolated and unoptimized yield.

^a Microwave irradiation was carried out at 600 W.

^b Isolated and unoptimized yield.