Novel and Efficient Synthesis of Pyrimidine Derivatives

Abstract

A new series of 1-alkyl-2-oxo-1,2-dihydro-pyrimidine-5-carboxalic acid amides is described. The reaction of N-((E)-3-(dimethylamino)-2-formylacryloyl) formamidine, an intermediate obtained by Vilsmeier–Haack formylation of acetonitrile with various mono-substituted ureas, provides such compounds in good yields.

Keywords:

• Monosubstituted ureas
• nucleophilic vinylic substitution
• pyrimidine derivatives
• synthesis

ACKNOWLEDGMENTS

The authors gratefully acknowledge financial support of this project by the University Grants Commission, New Delhi, India. We also thank Dr. V. B. Gaikwad for his valuable cooperation.