Abstract
A concise route for the syntheses of (±)-cherylline and latifine dimethyl ether is reported. The key steps involved are Michael addition of veratrole with p-methoxy nitrostyrene (for cherylline), anisole with 2,3-dimethoxy nitrostyrene (for latifine), and reduction of nitro intermediate, followed by Pictet–Spengler cyclization.
ACKNOWLEDGMENTS
We are grateful to SVNIT, Surat, and the Indian Institute of Chemical Technology, Hyderabad, for supporting this work.