Copper-Catalyzed Cross-Coupling Reactions of Methyl 13-Iodo-O-methylpodocarpate and Alcohols

Abstract

Copper iodide was utilized as a relatively inexpensive catalyst for the synthesis of podocarpic acid ether derivatives in excellent yields through the one-step cross-coupling reaction of methyl 13-iodo-O-methylpodocarpate with alcohols.

Keywords:

• Aryl ethers
• copper(I) iodide
• methyl 13-iodo-O-methylpodocarpate
• podocarpic acid

ACKNOWLEDGMENTS

This work was supported by the Chemistry Department of the University of Central Florida. The authors thank the Nebraska Center for Mass Spectrometry for providing the MS data.