Organocatalyzed One-Pot Synthesis of Substituted 1,5-Benzodiazepine and Benzimidazole Derivatives

Abstract

An efficient synthesis of some heterocycles is described by condensation between o-phenylenediamine and 1,3-dicarbonyl compounds catalyzed by L-proline. The reaction is carried out either at room temperature or reflux depending on the substrates.

Keywords:

• Diazepines
• β-diketones
• β-ketoesters
• L-proline
• o-phenylenediamine
• organocatalysis

ACKNOWLEDGMENTS

The work was carried out with under Grant No. SR/FTP/CS-15/2007 of the Department of Science and Technology, New Delhi, India. The director of the Indian Institute of Technology, Guwahati, is given special thanks for providing the required research facility to carry out the work.

Notes

^a Isolated yield.

^a Isolated yield.

^a Isolated yield.

^b The products were analyzed by ^IH NMR, ¹³C NMR, mass, and elemental analyses.