Convenient Electrochemical Method for the Synthesis of α-Bromo Alkyl Aryl Ketones

Abstract

An electrochemical procedure for the effective α-bromination of alkyl aryl ketones in excellent yield has been reported. The simple experimental procedure, catalyst-free conversion, and excellent yield of monobrominated products are the advantages of this method.

Keywords:

• Alkyl aryl ketone
• α-bromination
• carbonyl compounds
• constant-current electrolysis
• electrochemical bromination
• electrosynthesis

ACKNOWLEDGMENTS

The authors thank the Department of Science and Technology, India, for the financial support to carry out this work. The authors also thank the director of the Central Electrochemical Research Institute for his support and encouragement.

Notes

Note. Alkyl aryl ketone (10 mmol), acetonitrile (25 ml), and hydrobromic acid (10 ml of 47% solution) were electrolyzed at 10 ± 2 °C.

Note. Acetophenone (10 mmol), acetonitrile (25 ml), and hydrobromic acid (10 ml of 47% solution) were electrolyzed at 10 ± 2 °C, and the analysis was conducted after passing a charge of 2 F.