Abstract
An efficient synthetic method of six- and five-member nitrogen heterocyclic compounds was developed. Nitrogen heterocyclic compounds were prepared by condensation of the β-dicarbonyl compounds with the corresponding β- or γ-amino alcohols, subsequent cyclization, and spontaneous aromatization in the presence of a catalytic amount of Keggin-type heteropoly acids under very mild conditions.
ACKNOWLEDGMENT
The authors are thankful to Alzahra Research Council for the partial financial support.
Notes
a In all entries, 0.01 mmol H3PW12O40 was added to the reaction solution.
a Reaction conditions: Keggin-type heteropoly acids (0.01 mmol), 1,3-dicarbonyl compound (1 mmol), amino alcohol (1.5 mmol), solvent-free system, rt, 6 h.
a Reaction conditions: Keggin-type heteropoly acids (0.01 mmol), 1,3-dicarbonyl compound (1 mmol), amino alcohol (1.5 mmol), solvent-free system, rt, 6 h.
b Yields analyzed by gas chromatography.
Notes. Reaction conditions: Keggin-type heteropoly acids (0.01 mmol), 1,3-dicarbonyl compound (1 mmol), amino alcohol (1.5 mmol), solvent-free system, rt, 6 h.
a Yields were analyzed by gas chromatography.