Synthesis, Characterization, and Antimicrobial Studies of Bissydnones Based on 4,4′-Diaminodiphenyl Methane

Abstract

The aim of this investigation is to present the synthesis and characterization of some 3,3′-(methylenedi-1,4-phenylene)bis(4-substituted aminosulfonyl)sydnone (7a–j) and to evaluate their antimicrobial activity. All newly synthesized compounds were characterized by spectral data as well as by elemental analysis. Some compounds showed excellent activity against Gram-positive and Gram-negative bacteria.

Keywords:

• Bissydnone
• cyclization
• 4,4′-diaminodiphenyl methane
• mesoionic
• microbial

ACKNOWLEDGMENT

The authors are thankful to Atul Limited, Valsad, for providing some useful chemicals.

Notes

Notes. IZ, inhibition of zone; MIC, minimum inhibitory concentration. Zone diameter of growth inhibition (mm) after 24 h.