Abstract
A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100°C and the subsequent treatment of the nitrile with basic hydrogen peroxide. The resulting amide products were produced in good yields (67–95%) and purity (>95%).
ACKNOWLEDGMENTS
The authors gratefully acknowledge financial support from the Research Corporation, the University of Chattanooga Foundation, and the Grote Chemistry Fund.
Notes
a Isolated yields.
b Time for complete conversion to amide.