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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 13
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Original Articles

Indolizine Studies, Part 5: Indolizine-2-carboxamides as Potential HIV-1 Protease Inhibitors[Citation1]

, &
Pages 2018-2028 | Received 22 Apr 2009, Published online: 08 Jun 2010
 

Abstract

1,1-Carbonyldiimidazole-promoted coupling of Baylis–Hillman-derived indolizine-2-carboxylic acids with a range of amine and amino acid derivatives has provided access to the corresponding carboxamides in moderate to excellent yield.

ACKNOWLEDGMENTS

We are grateful to the National Research Foundation (NRF: GUN 2069255) for a bursary (M. T.) and to the NRF, the Medical Research Council of South Africa, and Rhodes University for generous financial support. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and therefore the NRF does not accept any liability.

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