Abstract
Epoxides are converted regioselectively to corresponding higher substituted alcohols with greater yields using diphosphorus tetraiodide (P2I4) as a reducing agent and a catalytic amount of tetraethylammonium bromide at room temperature.
ACKNOWLEDGMENT
V. N. T. and R. A. R. gratefully acknowledge the University Grants Commission, India, for financial support.
Notes
a Typically, P2I4 (0.01 mol) reacted with epoxide (0.01 mol) in dichloromethane (50 ml, 1–3% moisture) in the presence of a catalytic amount of TEAB at room temperature.
b Starting compounds were prepared by standard literature procedures.
c Isolated yields after column chromatography and structure confirmed by comparison of IR and 1H NMR with those of authentic materials.
d Optical purity was confirmed by chiral HPLC and optical rotation matches with literature values.[ Citation 11 , Citation 12 ]