Abstract
Regio-, stereo-, and chemoselective ring opening of epoxides with thiols using Cu/MgO as a heterogeneous catalyst has efficiently been carried out to produce the corresponding β-hydroxy sulfides in excellent yields at room temperature under solvent-free conditions. The treatment of the epoxides with thiols and 50% aqueous H2O2 in the presence of the same catalyst at room temperature affords the β-hydroxy sulfoxides in excellent yields.
ACKNOWLEDGMENTS
The authors thank the Council of Scientific and Industrial Research and the University Grants Commission, New Delhi, for financial assistance.
Notes
a The structures of the products were established from their spectral (1H NMR and MS) data.
b Yields reported in the parentheses are for other regioisomers.
a The structures of the products were established from their spectral (1H NMR and MS) data.
b Diastereomeric (82:18) mixture determined by 1H NMR analysis.
Part 170 in the series “Studies on Novel Synthetic Methodologies.”