p-Toluene Sulfonic Acid–Catalyzed, Solvent-Free Synthesis of Symmetrical Bisamides by Reaction Between Aldehydes and Amides

Abstract

Reaction between aldehydes and amides catalyzed by p-toluene sulfonic acid in solvent-free conditions provided a simple and efficient one-pot route for the synthesis of symmetrical bisamide derivatives in excellent yields.

Keywords:

• Aldehydes
• amides
• bisamides
• p-toluene sulfonic acid
• solvent-free reaction

Notes

^a Reaction conditions: 4-bromobenzaldehyde (1.0 mmol), acetamide (2.2 mmol), neat, 100 °C.

^b Isolated yield.

^a Isolated yield.