Abstract
The solid–liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidazole, benzimidazole, and indole-3-carbaldehyde) was carried out under different conditions. The use of alkali carbonate in dimethylformamide or in MeCN (in the latter case, in the presence of a phase-transfer catalyst) is a suitable method to prepare the corresponding N-alkylated products in an efficient way. In most cases, the solventless, microwave-assisted reaction is an environmentally friendly alternative to traditional methods.
Notes
a Determined on the basis of GC or LC.
Note. Because of the risk of explosion, the reaction of carbazole and ethyl halogenoacetates may be dangerous above 100 °C under MW conditions.
a Determined on the basis of GC.
a Determined on the basis of GC.
a Determined on the basis of GC.
a Determined on the basis of GC.