Synthesis of Chlorin-Fused Monospirooxindolopyrrolidines Through a Facile [3 + 2]-Cycloaddition of Azomethine Ylides

Abstract

One-pot synthesis of novel chlorin-fused monospirooxindolopyrrolidines has been accomplished in good yield via a facile [3 + 2]-cycloaddition reaction of azomethine ylides, derived from isatin/N-benzylisatin and sarcosine, with various porphyrin derivatives as dipolarophiles.

Keywords:

• Azomethine ylide
• cycloaddition
• oxindolopyrrolidines
• porphyrin
• spiroheterocycles

ACKNOWLEDGMENTS

A. R. S. thanks the Council of Scientific and Industrial Research (CSIR) for the award of a senior research fellowship. P. S. thanks the University of Madras for a University Grants Commission junior research fellowship. R. R. thanks the Department of Science and Technology (DST) and DST–Funding for Infrastructure in Science and Technology (FIST), New Delhi, for financial support.