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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 16
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Original Articles

Efficient and Convenient Protocol for the Synthesis of Novel 1,2,4-Triazolo[3,4-b][1,3,4]Thiadiazines

, &
Pages 2421-2428 | Received 05 Jun 2009, Published online: 26 Jul 2010
 

Abstract

The novel triazolothiadiazine analogs 5a–p were obtained via a multistep synthetic sequence beginning with 5-substituted 4-amino-1,2,4-triazole-3-thiols 1. Compound 1, in reaction with various aromatic aldehydes 2 in acetic acid, afforded Schiff bases 3a–p. Cyclization of 3a–p with ethyl chloroacetate 4 in the presence of sodium hydride at room temperature gave triazolothiadiazines 5a–p in good yields.

ACKNOWLEDGMENT

We gratefully acknowledge the financial support from the Research Council of Arak University.

Notes

a Isolated yields.

a Isolated yields.

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