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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 40, 2010 - Issue 17
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Original Articles

Simple and Efficient Synthesis of Belinostat

Lei Yang Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China; Center of Drug Discovery, China Pharmaceutical University, Nanjing, China
,
Xiaowen Xue Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, ChinaCorrespondence[email protected]
&
Yihua Zhang Center of Drug Discovery, China Pharmaceutical University, Nanjing, China
Pages 2520-2524 | Received 05 May 2009, Published online: 05 Aug 2010
 
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Abstract

A novel synthesis of belinostat (1) starting from 3-nitrobenzaldehyde has been developed. The key step in this sequence involves the conversion of (2E)-3-(3-aminophenyl)acrylic acid methyl ester to (2E)-3-(3-chlorosulfonylphenyl)acrylic acid methyl ester via diazotization and sulfonylation.

ACKNOWLEDGMENT

This work was supported by funding from the China Pharmaceutical University (No. 211080).

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