Efficient and Novel Synthesis of Benzoxazole Derivatives in the Presence of Zinc Dust Under Solvent-Free Conditions

Abstract

A mild and efficient method has been developed for the synthesis of 2-cyclic amine-substituted benzoxazole derivatives using zinc dust under microwave irradiation in the absence of solvent is described. A comparative study was performed under conventional and microwave heating conditions. Zinc dust can be reused several times after reactivation. The significant feature of this method is the isolation of the pure product by simple workup in a short reaction time with high purity.

Keywords:

• Benzoxazole
• cyclic amine
• microwave
• solvent free
• zinc dust

ACKNOWLEDGMENT

K. R. R. and R. V. R thank the Council of Scientific and Industrial Research (CSIR, New Delhi, India) for the award of fellowships.

Notes

^a All the products were characterized by ¹H NMR, IR and mass spectroscopy.

^b Isolated and optimized yields.