Glycine-Catalyzed Efficient Synthesis of Pyranopyrazoles via One-Pot Multicomponent Reaction

Abstract

A facile and convenient protocol is developed for the fast (5–20 min) and high-yielding (85–95%) synthesis of fused pyranopyrazoles from ethyl acetoacetate, hydrazine hydrate, an aldehyde, and malononitrile in the presence of nontoxic, simple, and readily available organocatalyst glycine in aqueous medium at 25 °C.

Keywords:

• Aldehydes
• ethylacetoacetate
• glycine
• hydrazine hydrate
• malononitrile
• pyranopyrazoles
• water

Notes

^a All the products were known and characterized by comparison with the authentic samples.

^b Yield refers to isolated product.