Sodium Dihydrogen Phosphate as an Efficient Catalyst for One-Pot, Three-Component Synthesis of α-Aminophosphonates Under Solvent-Free Conditions at Room Temperature

Abstract

A simple, efficient, and general method has been developed for the one-pot, three-component synthesis of α-aminophosphonates from a condensation reaction of trimethyl phosphite, aldehydes, and amines in the presence of sodium dihydrogen phosphate under solvent-free conditions. Thus, α-aminophosphonates were synthesized relatively quickly in good yields at room temperature.

Keywords:

• α-Aminophosphonates
• room temperature
• sodium dihydrogen phosphate
• solvent-free
• trimethyl phosphite

ACKNOWLEDGMENT

We gratefully acknowledge the financial support from the Research Council of Islamic Azad University of Firoozabad.

Notes

^a All reactions are carried out under same conditions as Table 1, entry a.