Synthesis of 2′-C-Methyl Ribonucleoside Analogues with Modified Heterocyclic Base Moieties

Abstract

Recently, 2′-C-methyl nucleoside analogues have been reported to exhibit potent anti–hepatitis C virus (HCV) activity through inhibition of HCV RNA replication without significant cytotoxicity. As a part of our continuous efforts of searching for novel antiviral agents, we now report the synthesis of heterobase-modified 2′-C-methyl ribonucleoside analogues.

Keywords:

• Antiviral agent
• HCV
• 2′-C-methyl nucleoside