Abstract
A one-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles with two identical substituents directly from the reaction of nitriles and hydroxylamine hydrochloride in the presence of potassium fluoride as catalyst and solid support under solvent-free condition is described. Moreover, the formation of products has been discussed, and a plausible mechanism has been presented. Simplicity of the process, workup in aqueous media, and excellent yields are some advantages of this method.
ACKNOWLEDGMENT
The authors gratefully acknowledge the Research Council of K. N. Toosi University of Technology for partial financial support of this work.
Notes
a All reactions were performed at 100 °C for 12 h.
b Isolated yields.
c 1 h after the reaction.
a All reactions were performed with 2 mmol nitrile, 2 mmol hydroxylamine hydrochloride, and 1 g potassium fluoride at 100 °C for 12 h.
b Isolated yields.