Abstract
A facile and an efficient strategy for the synthesis of multisubstituted pyrrole derivatives was developed using an unusual ring annulation of dialkyl acetylene dicarboxylic ester and α-amino acids with transition-metal oxides such as mercuric(II) oxide and silver(I) oxide and complexes such as ceric ammonium nitrate (CAN) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) as catalysts.
ACKNOWLEDGMENTS
The authors are thankful to Dr. J. S. Yadav, director, Indian Institute of Chemical Technology, Hyderabad, India, for his constant encouragement, and they are also thankful to the industry for financial support.