Ecofriendly and Efficient One-Pot Procedure for the Synthesis of Quinazoline Derivatives Catalyzed by an Acidic Ionic Liquid Under Aerobic Oxidation Conditions

Abstract

A three-component condensation reaction between 2-aminobenzophenone derivatives, formaldehyde or aromatic aldehydes, and ammonium acetate efficiently provides substituted quinazolines in a one-pot reaction in the presence of Brönsted acidic ionic liquid, 1-methylimidazolium triflouroacetate ([Hmim]TFA), in conjunction with aerobic oxidation. The ionic liquid was separated from the reaction mixture by simple extraction and was recycled three times without considerable loss in activity.

Keywords:

• Aerobic oxidation
• catalysis
• heterocycles
• multicomponent
• quinazolines

ACKNOWLEDGMENT

We gratefully acknowledge financial support from the Research Council of Shahid Beheshti University and the Catalyst Center of Excellence (CCE).

Notes

^a Isolated yield after 2 h.

^a Isolated yield.