Abstract
A series of β-amino alcohols derivatives were synthesized from (R)-2-amino-1-butanol and (S)-1,2-propanediol, and they have been used as organocatalaysts in the racemic ring opening of epoxide in good yields with high enantiomeric excess (up to 97%).
ACKNOWLEDGMENT
We thank the Scientific and Technological Research Council of Turkey (TUBİTAK) for their financial support (Project No. 107 T 079).
Notes
a Isolated yield by preparative TLC.
b Determined by HPLC analysis on a Chiralcel OD-H column.
c Absolute configuration was determined by comparison of HPLC retention times with those of products of chiral molecules.